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Easton's 1897 Bible Dictionary (easton)

Mesopotamia
the country between the two rivers (Heb. Aram-naharaim; i.e.,
"Syria of the two rivers"), the name given by the Greeks and
Romans to the region between the Euphrates and the Tigris (Gen.
24:10; Deut. 23:4; Judg. 3:8, 10). In the Old Testament it is
mentioned also under the name "Padan-aram;" i.e., the plain of
Aram, or Syria (Gen. 25:20). The northern portion of this
fertile plateau was the original home of the ancestors of the
Hebrews (Gen. 11; Acts 7:2). From this region Isaac obtained his
wife Rebecca (Gen. 24:10, 15), and here also Jacob sojourned
(28:2-7) and obtained his wives, and here most of his sons were
born (35:26; 46:15). The petty, independent tribes of this
region, each under its own prince, were warlike, and used
chariots in battle. They maintained their independence till
after the time of David, when they fell under the dominion of
Assyria, and were absorbed into the empire (2 Kings 19:13).